腫瘤轉(zhuǎn)移英文-課件

1、Cancer metastasisCancer metastasisWhat is metastasis?What is metastasis?Cancer Stem Cells motivate and maintain the growth of cancer cellspotentiality plasticity make them easy to surviveHypothesis of tumor metastasisCancer Stem Cells motivate aThe phases of Cancer metastasisThe mechanism of cancer

2、metastasisMalignant Tumor metastasis pathway Tumor metastasisThe molecules in the metastasis The phases of Cancer metastasiThe phases of Cancer metastasis俞仁濤Invasion(侵犯)Intravasation（內(nèi)滲）Extravasation（外滲）The phases of Cancer metastasiInvasion1.Stable cell movable cell 2.Protein expression3.Movement m

3、echanismRelative genesInvasion1.Stable cell 腫瘤轉(zhuǎn)移英文-課件Intravasation1.Angiogenesis 2.Immune escape Intravasation1.Angiogenesis ExtravasationThe inverse process of invasionExtravasationThe inverse proceTHE PROCESS OF TUMOR METASTASISTHE PROCESS OF TUMOR METASTASIMalignant Tumor metastasis pathway 惡性腫瘤常

4、見的轉(zhuǎn)移途徑Malignant Tumor metastasis patCommon metastasis pathway 1.lymphatic metastasis 淋巴道轉(zhuǎn)移2.hematogenous metastasis 血道轉(zhuǎn)移3. implantation metastasis 種植性轉(zhuǎn)移Common metastasis pathway 1.lProcess ： cancer cell lymph vessel regional lymph node beyond lymph node hematogenous metastasis1. Lymphatic metastasiz

5、eProcess ： cancer cell 2.Hematogenous metastasislungliver2.Hematogenous metastasislunglMetastasis pathway（1） Body vein lung（2） Portal vein liver（3） pulmonary veins Total body （ brain 、 bone 、 kidney 、 adrenal glands ） Metastasis pathway（1） Body vei3.Implantation metastasis ChestCeliacPericardial cav

6、ity3.Implantation metastasis ChesBioremediation 生物治療Low side effectsWide rangeClear goalBioremediation 生物治療Low side eMechanism of cell metastasisCell adhesion molecule(CAM)Degradation of extracellular matrixMotility of tumor cellsFormation of vessels Regulation of gene expressionImmunizationMechanis

7、m of cell metastasisCeCell adhesion molecule(CAM)CadherinIntegrinsSelectinIgSFothersCell adhesion molecule(CAM)Cad Degradation of extracellular matrix Degradation of extracellular 絲氨酸蛋白酶類 半胱氨酸蛋白酶類（ Caspase家族）天冬氨酸蛋白酶類 基質(zhì)金屬蛋白酶類（MMPs）Degradation of extracellular matrix Proteoiytic enzymes (蛋白水解酶)溶解ECME

8、CM是腫瘤侵襲和轉(zhuǎn)移的天然屏障絲氨酸蛋白酶類 Degradation of eMotility of tumor cells Motility types: Random movement Directional movement Motility factors:AutoecrineparacrineMotility of tumor cells MotiFormation of vesselsTumor metastasis relys on the forming of vessels.Formation of vesselsTumor metBrief Introduction to

9、Molecules in Cancer Metastasis腫瘤轉(zhuǎn)移英文-課件Three SectionsTumour angiogenesis DisaggregationIntravasationThree SectionsTumour angiogeneTumour angiogenesis Tumour angiogenesis has laid the foundation for tumour survival and tumour metastasis .Tumour angiogenesis Tumour angTumour angiogenesis Tumour angiogenes