生物化學(xué)I(英).doc

生物化學(xué)I（英）課程號(hào)：07110110 周學(xué)時(shí)：3-0 學(xué)分： 3.0英文名稱：Biochemistry (A) I一、教學(xué)目的與教學(xué)要求：本課程將作為學(xué)生全面進(jìn)行現(xiàn)代生物學(xué)其他課程學(xué)習(xí)的最重要基礎(chǔ)課程，著重開(kāi)展有關(guān)生物化學(xué)基礎(chǔ)（生命的分子理論，細(xì)胞，生物分子，水）、分子構(gòu)造和觸媒作用（氨基酸，多肽和蛋白質(zhì)，蛋白質(zhì)的三級(jí)構(gòu)造，蛋白質(zhì)的功能，酶學(xué)，碳水化合物及糖生物學(xué)，核苷酸及核酸，脂肪，生物膜及運(yùn)輸，生物信號(hào)）、新陳代謝（生物能學(xué)原理，糖酵解，檸檬酸循環(huán)，脂肪酸氧化，氨基酸氧化及尿形成，氧化磷酸化及光化磷酸化，碳水化合物的合成，脂肪合成，氨基酸、核酸的合成）及信息通路（基因和染色體，DNA代謝，RNA代謝，蛋白質(zhì)代謝，基因表達(dá)的調(diào)控，DNA重組技術(shù)）四個(gè)專題的講授工作。課程結(jié)合經(jīng)典的和最新的科學(xué)研究實(shí)例來(lái)闡述基本理論和概念，對(duì)生化實(shí)驗(yàn)技能具有重要的理論指導(dǎo)意義，并為學(xué)生今后從事生命科學(xué)相關(guān)的工作打下基礎(chǔ)。二、主要內(nèi)容及學(xué)時(shí)分配（48學(xué)時(shí)）：1. The Molecular Logic of Life and Cell 3學(xué)時(shí)The chemical unity of diverse living organism, Energy production and consumption in metabolism, Biological information transfer, Cells and tissues used in biochemical studies, Evolution and structures of prokaryotic and eukaryotic cells, Study of cellular components, Viruses.2. Biomolecues and Water 3學(xué)時(shí)Chemical composition and bonding, Three-dimensional structure: configuration and conformation, Chemical reactivity, Macromolecules and their monomeric subunits, Prebiotic evolution, Weak interactions in aqueous systems, Ionization of water, weak acids, and Weak bases, Buffering against pH changes in biological systems, Water as a Reactant, The fitness of the aqueous environment for living organisms.3. Amino Acids, Peptides, and Proteins 6學(xué)時(shí)Amino acids, Peptides and proteins, Working with proteins, The covalent structure of proteins.4. The Three-Dimentional Structure of Proteins 3學(xué)時(shí)Overview of protein structure, Protein secondary structure, Protein tertiary and quaternary structures, Protein denaturation and folding.5. Protein Function 3學(xué)時(shí)Reversible binding of a protein to a ligand: oxygen-binding proteins, Complementary interactions between proteins and ligands: the immune system and immunoglobulins, Protein interactions modulated by chemical energy: actin, myosin, and molecular motors.6. Enzymes 6學(xué)時(shí)An introduction to enzymes, How enzymes work, Enzyme kinetics as an approach to understanding mechanism, Examples of enzymatic reactions, Regulatory enzymes.7. Lipids 3學(xué)時(shí)Storage Lipids, Structural Lipids in Membranes, Lipids as Signals, Cofactors, and Pigments, Separation and Analysis of Lipids.8. Biological Membranes and Transport 3學(xué)時(shí)The molecular constituents of membranes, The supramolecular architecture of membranes, Solute transport across membranes.9. Biosignaling, Structure and Function of Hormones 3學(xué)時(shí)Molecular mechanisms of signal transduction, Gated ion channels, Receptor enzymes, G protein-coupled receptors and second messengers, Sensory transduction in vision, olfaction, and gestation, Structure and function of hormones, Regulation of hormone., Regulation of transcription by steroid hormones, Regulation of the cell cycle by protein kinases, Oncogenes, tumor suppressor genes, and programmed cell death. 10. Nucleotides and Nucleic Acids 3學(xué)時(shí)Some basics, Nucleic acid structure, Nucleic acid chemistry, Other functions of nucleotides.11. Genes and Chromosomes 3學(xué)時(shí)Chromosomal Elements, The Size and Sequence Structure of DNA Molecules, DNA Supercoiling, Chromatin and Nucleoid Structure.12. DNA Metabolism 6學(xué)時(shí)A Word about Terminology, DNA Replication, DNA Repair, DNA Recombination.13. RNA Metabolism 3 學(xué)時(shí)DNA-Dependent Synthesis of RNA, RNA Processing, RNA-Dependent Synthesis of RNA and DNA.三、相關(guān)教學(xué)環(huán)節(jié)安排（含考試要求）：1. 教學(xué)使用多媒體形式，全英文講授；2. 每章安排一次作業(yè)，要求用英文答題；3. 閉卷考試，英語(yǔ)試卷，答卷要求用英語(yǔ)。四、推薦教材或參考書：1. Lehninger Principles of Biochemistry, Third Edition, David L. Nelson and Micheal M. Cox, Worth Publishers, 2000.2. 生物化學(xué)(第3版), 王鏡巖 主編, 高等教育出版社, 2002.3. 生物化學(xué)導(dǎo)論(第2版), Trudy Mckee & James R. Mckee, 科學(xué)出版社, 2000.生物化學(xué)II（英）課程號(hào)：07110120 周學(xué)時(shí)：2-0 學(xué)分： 2.0英文名稱：Biochemistry (A) II一、教學(xué)目的與教學(xué)要求：本課程將作為學(xué)生全面進(jìn)行現(xiàn)代生物學(xué)其他課程學(xué)習(xí)的最重要基礎(chǔ)課程，著重開(kāi)展有關(guān)生物化學(xué)基礎(chǔ)（生命的分子理論，細(xì)胞，生物分子，水）、分子構(gòu)造和觸媒作用（氨基酸，多肽和蛋白質(zhì)，蛋白質(zhì)的三級(jí)構(gòu)造，蛋白質(zhì)的功能，酶學(xué)，碳水化合物及糖生物學(xué)，核苷酸及核酸，脂肪，生物膜及運(yùn)輸，生物信號(hào)）、新陳代謝（生物能學(xué)原理，糖酵解，檸檬酸循環(huán)，脂肪酸氧化，氨基酸氧化及尿形成，氧化磷酸化及光化磷酸化，碳水化合物的合成，脂肪合成，氨基酸、核酸的合成）及信息通路（基因和染色體，DNA代謝，RNA代謝，蛋白質(zhì)代謝，基因表達(dá)的調(diào)控，DNA重組技術(shù)）四個(gè)專題的講授工作。課程結(jié)合經(jīng)典的和最新的科學(xué)研究實(shí)例來(lái)闡述基本理論和概念，對(duì)生化實(shí)驗(yàn)技能具有重要的理論指導(dǎo)意義，并為學(xué)生今后從事生命科學(xué)相關(guān)的工作打下基礎(chǔ)。二、主要內(nèi)容及學(xué)時(shí)分配（32學(xué)時(shí)）：14. Principles of Bioenergetics 2學(xué)時(shí)Bioenergetics and thermodynamics, Phosphoryl group transfer and ATP, Biological oxidation-reduction reactions.15. Carbohydrates and Glycobiology 2學(xué)時(shí)Monosaccharides and disaccharides, Polysaccharides, Glycoconjugates: proteoglycans, glycoproteins, and glycolipids, Analysis of carbohydrates.16. Glycolysis and the Catabolism of Hexoses 6學(xué)時(shí)Glycolysis, Fates of pyruvate under aerobic and anaerobic conditions, Feeder pathways for glycolysis, Regulation of carbohydrate catabolism, The pentose phosphate pathways of glucose oxidation.17. The Citric Acid Cycle 2學(xué)時(shí)Production of acetate, Reactions of the citric acid cycle, Regulation of the citric acid cycle, The glyoxylate cycle.18. Oxidation of Fatty Acids 2學(xué)時(shí)Digestion, mobilization, and transport of fats, oxidation, Ketone bodies.19. Amino Acid Oxidation and the Production of Urea 2學(xué)時(shí)Metabolic fates of amino groups, Nitrogen excretion and the urea cycle, Pathways of amino acid degradation.20. Oxidative Phosphorylation and Photophosphorylation 2學(xué)時(shí)(Oxidative phosphorylation), Electron-transfer reactions in mitochondria, ATP synthesis, Regulation of oxidative phosphorylation, (Photosynthesis: harvesting light energy), General features of photophosphorylation, Light absorption, The central photochemical event: light-driven electron flow, ATP synthesis by photophosphorylation.21. Carbohydrate Biosynthesis 2學(xué)時(shí)Gluconeogenesis, Biosynthesis of glycogen, starch, sucrose, and other carbohydrates, Photosynthetic carbohydrate synthesis, Regulation of carbohydrate metabolism in plants.22. Lipid Biosynthesis 2學(xué)時(shí)Biosynthesis of fatty acids and eicosanoids, Biosynthesis of triacylglycerols, Biosynthesis of membrane phospholipids, Biosynthesis of cholesterol, steroids, and isoprenoids.23. Biosynthesis of Amino Acids, Nucleotides, and Related Molecules 2學(xué)時(shí)Overview of nitrogen metabolism, Biosynthesis of