過(guò)敏性鼻炎的診斷和治療.ppt

Nasal mucosal hyperreactive rhinopathy Allergic Rhinitis (AR) Perennial(PAR), Seasonal(SAR) （Pollinosis） Morbidity: 10%20% Inhalant allergensdust mite, house dust, pollen, fungi, animal danders, cockroach； Food allergensmilk, eggs, fish and shrimp, meat, vegetables, fruits.,Mite,Mold,Pollen,Cat,Antigens for allergic rhinitis,變應(yīng)性鼻炎的病因?qū)W,內(nèi)在因素遺傳因素：有家族史者較無(wú)家族史者發(fā)病危險(xiǎn)高倍母系第對(duì)染色體長(zhǎng)臂段 外在因素（環(huán)境因素）：基因表達(dá)受非遺傳因素影響。對(duì)孿生兒，同時(shí)有AR 癥狀者為 易感個(gè)體在一定環(huán)境條件作用下才發(fā)病,變應(yīng)原與致敏靶細(xì)胞表面IgE結(jié)合,致敏靶細(xì)胞脫粒、釋放、合成生物活性介質(zhì),肥大細(xì)胞,儲(chǔ)備的介質(zhì),新合成的介質(zhì),組胺,緩激肽,白三烯,血小板活化因子,前列腺素D2,毛細(xì)血管擴(kuò)張、通透性增加，腺體分泌增多,嗜酸/堿性粒細(xì)胞,哮喘,鼻炎,發(fā)病機(jī)制,Pathology： Type allergy Allergic inflammation: Predominant T cells & eosinophilic cells infiltrate.,Symptoms & Signs： Nasal irritation and iching recurrent attacks of paroxysmal sneezing copious watery rhinorrhea nasal obstruction,鼻后滴漏,Diagnosis： 1、History（allergen exposure, hypersensitivity, family history） 2、Examination 3、Skin test: skin prick test 4、IgE antibody，Serum total IgE 、special IgE 5、Nasal provocation or nasal chanllenge tests,Differential Diagnosis： 1、Vastomotor rhinitis 2、Nonallergic rhinitis with eosinophilia syndrome, NARES 3、Hyperreflectory rhinitis 4、Acute rhinitis,Complications： 1、Allergic sinusitis 2、Asthma 3、Secretory otitis media 4、Allergic pharyngolaryngitis Treatment： 1、Avoidance,2、Drugs 1）Antihistamines 2）Corticosteroids 3）Sodium cromoglycate(SCG) Cromolyn sodium 4）Anticholinergic agents 5）Vasoconstrictor sympasthomimetics 3、Hyposensitization 4、Others：Traditional Chinese medicine, laser, operation,Nasal Polyp & Nasal Polyposis Etiology：mutilfactors 1.allergic；2.chronic inflammation Pathology：highly swelled connective tissue. Predominant eosinophilic cells infiltrate. Lymphatic cells, neutrophils, basophils, mast cells.,Polyp in maxillary sinus（L），polyp in middle meatus（R）,Symptoms & Sign：persistent nasal obstruction，close nasal sound，hyposmia, rhinorrhea, snore, “frog nose”,Antrochoanal polyp,Antrochoanal polyp,Diagnosis： Anterior rhinoscopy：translucent, soft, smooth masses. Endoscopy, X-ray and CT scanner. Differential Diagnosis： Papilloma inverted，angiofibroma of nasopharynx，malignant tumor of nasal cavity，meningoencephalocele Treatment：1、conservative treatmentcorticosteroids 2、surgical treatment,Polyps（above），papilloma（below）,papilloma（L），MT of nasal cavity （R）,Sinusitis Acute suppurative sinusitis Features of sinus anatomy： 1、small ostia of the sinuses； 2、continuative mucosa between nasal cavity and sinuses； 3、contiguous of the ostia； 4、location of the astia and features of the sinuses.,Frontal Sinus,Ethmoid Sinus Maxillary Sinus,Etiology： 1、General factors: Poor general health (influenza, measles, whooping cough) 2、Local factors： Sinus diseases； Infective focus of eripheral organs， Direct infection； Nasal tampon (packing)； Rapid change of atmospheric pressure,ABS主要病原體：肺炎鏈球菌和嗜血流感桿菌,SAHP. Otolaryngol Head Neck Surg. 2004;130:1-45.,20-43%,22-35%,Anaerobes 0-9%,Staphylococcus aureus 0-8%,Other bacteria 4%,Moraxella catarrhalis,Other streptococci 3-9%,2-10%,S. pneumoniae,成人Acute bacterial rhinosinusitis (ABS)病因,H. influenzae,兒童Acute bacterial rhinosinusitis (ABS)病因,ABS主要病原體：肺炎鏈球菌、嗜血流感桿菌和卡他莫拉菌,Otolaryngol Head Neck Surg. 2004;130:1-45.,Symptoms & Signs： General symptoms： Malaise, fever. Local symptoms: 1）Nasal obstruction sustained, with hyposmia 2） Suppurative rhinorrhea, streaky with blood, foul smell(odontogentic) 3）headach or local ache,Antral painfrom inner canthus downwards across the cheek, upper alveolus on the affected side. Ethmoidal painover bridge of the nose & inner canthus behind the eye. Frontal painforehead, periodicity, persist for an hour or tow after getting up in the morning, and clear during the afternoon. Sphenoidal painoccipital or vertical headache.,Diagnosis： History， Signs, Anterior rhinoscopy, Nasal endoscopy, Radiological examination, Puncture and irrigation of maxillary sinus,Treatment：Eradicate causes，keep drainage；control infection and prevent complications 1、General treatment：take rest，antibiotics，antihistamine (if necessary ) 2、Local treatment 3、Body drainage 4、Physical therapy 5、 Puncture and irrigation of maxillary sinus,Maxillary sinus puncture and irragation,Chronic suppurative sinusitis Etiology：AcuteChronic Symptoms & Signs： General: Local： rhinorrhea, nasal obstruction, headache, hyposmia, vision disorder,Diagnosis： 1、History； 2、Examination：anterior rhinoscopy, nasal endoscopy 3、Radiological examination：CT or MRI 4、Puncture and irrigation of sinus,Normal image of nasal endoscopy,Maxillary sinusitispus in the middle meatus,Maxillary sinusitis(R),Sphenoid sinusitispus in the sphenoethmoidal recess,Sphenoid sinusitis,Pansinusitis,Pansinusitis,Treatment： 1、Intranasal medications：Corticosteroid， Vasoconstrictor sympasthomimetics 2、Puncture and irrigation of maxillary sinus 3、Displacement methodfrontal sinusitis, ethmoidal sinusitis, sphenoidal sinusitis,