YAP-TAZ-TEAD-IN-2-生命科學(xué)試劑-MCE

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEYAP/TAZ-TEAD-IN-2Cat.No.:HY-168704分?式:C??H??N?O?S分?量:356.44作?靶點:YAP;TAMReceptor;Survivin作?通路:StemCell/Wnt;ProteinTyrosineKinase/RTK;Apoptosis儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性YAP/TAZ-TEAD-IN-2(Compound51)?個抑制YAP/TAZ與TEAD之間相互作?的YAP/TAZ-TEAD抑制劑。YAP/TAZ-TEAD-IN-2抑制TEAD的轉(zhuǎn)錄活性,其IC501.2nM。YAP/TAZ-TEAD-IN-2抑制YAP/TAZ-TEAD靶(Cyr61,CTGF,AXL和Survivin)表達(dá)和乳腺癌細(xì)胞增殖[1]。體外研究YAP/TAZ-TEAD-IN-2(2.5-20μM,72h)dose-dependentlyinhibitsMDA-MB-231cellsproliferationwithIC50of4.4μM[1].YAP/TAZ-TEAD-IN-2(1-10μM,48h)inhibitstheexpressionoffourmajorYAP/TAZ-TEADtargetproteins,i.e.,Cyr61,CTGF,AXLandBIRC5(Survivin)inMDA-MB-231cells[1].CellProliferationAssay[1]CellLine:MDA-MB-231cellsConcentration:2.5,5,10,20μMIncubationTime:72hResult:Dose-dependentlyinhibitedMDA-MB-231cellsproliferationwithIC50of4.4μM.CellProliferationAssay[1]CellLine:MDA-MB-231cellsConcentration:1,5,10μMIncubationTime:48h1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEResult:Dose-dependentlyinhibitedthefourprincipalYAP/TAZ-TEADtargetproteins,namelyCyr61,CTGF,AXLandBIRC5(Survivin).REFERENCES[1].Toulotte,etal.TowardsthedesignofligandsoftheinternalpocketTEADsC-terminaldomain.Europeanjournalofmedicinalchemistry,2025,282,117026.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>