Thalidomide-O-amido-C6-NH2-TFA-Cereblon-Ligand-Linker-Conjugates-11-TFA-DataSheet-生命科學(xué)試劑-MedChemExpress

Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEThalidomide-O-amido-C6-NH2TFACat.No.:HY-112618ACASNo.:1950635-14-9Synonyms:CereblonLigand-LinkerConjugates11TFA;E3LigaseLigand-LinkerConjugates25TFA分?式:C??H??F?N?O?分?量:544.48作?靶點(diǎn):E3LigaseLigand-LinkerConjugates作?通路:PROTAC儲(chǔ)存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:≥105.5mg/mL(193.76mM)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM1.8366mL9.1831mL18.3661mL5mM0.3673mL1.8366mL3.6732mL10mM0.1837mL0.9183mL1.8366mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性Thalidomide-O-amido-C6-NH2TFA(CereblonLigand-LinkerConjugates11TFA)?種合成的E3連接酶配體-linker偶聯(lián)物，包含于Thalidomide的cereblon配體和1個(gè)linker。可?于合成PROTAC分?[1]。1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEIC50&TargetCereblon體外研究PROTACscontaintwodifferentligandsconnectedbyalinker;oneisaligandforanE3ubiquitinligaseandtheotherisforthetargetprotein.PROTACsexploittheintracellularubiquitin-proteasomesystemtoselectivelydegradetargetproteins[1].REFERENCES[1].BradnerJ,etal.Targetedproteindegradationtoattenuateadoptivet-celltherapyassociatedadverseinflammatoryresponses.WO2017024318A1McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>