Desmethyl-Erlotinib-OSI-420-DataSheet-MedChemExpress

1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDesmethyl ErlotinibCat. No.: HY-13256CAS No.: 183320-51-6Synonyms: OSI-420; CP-473420分式: CHClNO分量: 415.87作靶點: EGFR作通路: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C

2、 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 4.2 mg/mL (10.10 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.4046 mL 12.0230 mL 24.0460 mL5 mM 0.4809 mL 2.4046 mL 4.8092 mL10 mM 0.2405 mL 1.2023 mL 2.4046 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物

3、活性 Desmethyl Erlotinib (OSI-420)erlotinib 的活性代謝物，erlotinib 為表長因受體酪氨酸激酶 (EGFRtyrosin kinase) 抑制劑。體內(nèi)研究Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinibclearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmet

4、hyl Erlotinib1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEis 1.戶使本產(chǎn)品發(fā)表的科研獻 Eur J Pharm Sci. 2019 Apr 1. pii: S0928-0987(19)30135-6.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenousadministration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008, 62(3), 387-392.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;/p>