腫瘤干細胞-課件（PPT演示）

腫瘤干細胞腫瘤干細胞Cancer Stem Cell Pluripotent 2. 成體干細胞成體干細胞 (somatic stem cell, adult stem cell, ASC);3. 骨髓干細胞骨髓干細胞 (bone marrow derived stem cell, BMSC)或造血干細胞或造血干細胞 (hematopoietic stem cell， HSC)n 根據(jù)干細胞的發(fā)育潛能分為三類：根據(jù)干細胞的發(fā)育潛能分為三類：1. 全能干細胞全能干細胞 (totipotent stem cell,TSC)、2. 多能干細胞（多能干細胞（ pluripotent stem cell）3. 單能干細胞（單能干細胞（ unipotent stem cell）。）。Hui H et al: Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas. 2010 Apr;39(3):315-22.Induced differentiation of human ESYderived cells in cultureDisappearance of stem cell markers and appearance of pancreatic A-cell markers during the human embryonic cell differentiationHui H et al: Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas. 2010 Apr;39(3):315-22.Expression of hedgehog signal molecules during the human embryonic cell differentiation.Hui H et al: Glucagon like peptide-1-directed human embryonic stem cells differentiation into insulin-producing cells via hedgehog, cAMP, and PI3K pathways. Pancreas. 2010 Apr;39(3):315-22.干細胞起源？干細胞起源？體細胞克隆和干細胞克隆體細胞克隆和干細胞克隆體細胞克隆即取出一個雙倍體細胞核移入一個去核的卵細胞，并在一定條件下進行核卵重組，再植入代孕母體中發(fā)育成新個體的過程。供體細胞均來自高度分化的體細胞，其種類繁多、數(shù)量無限。 。 克隆人類胚胎則是將卵細胞的遺傳物質取出，只留下卵細胞中具有激發(fā)胚胎生長能力的細胞胞漿，然后將外源供者成熟體細胞的注入卵子。這種結合了 “外來 ”